2023 Publications

• Alexander BT, South AM, August P, Bertagnolli M, Ferranti EP, Grobe JL, Jones EJ, Loria AS, Safdar B, Sequeira-Lopez MLS; American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health. Appraising the preclinical evidence of the role of the renin-angiotensin-aldosterone system in antenatal programming of maternal and offspring cardiovascular health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. Hypertension. 2023 May;80(5):e75-e89. doi: 10.1161/HYP.0000000000000227. Epub 2023 Mar 23. PMID: 36951054.
• Badmus OO, Hinds TD Jr, Stec DE. Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease. Curr Hypertens Rep. 2023 Aug;25(8):151-162. doi: 10.1007/s11906-023-01242-8. Epub 2023 May 16. PMID: 37191842.
• Badmus OO, Kipp ZA, Bates EA, da Silva AA, Taylor LC, Martinez GJ, Lee WH, Creeden JF, Hinds TD Jr, Stec DE. Loss of hepatic PPARα in mice causes hypertension and cardiovascular disease. Am J Physiol Regul Integr Comp Physiol. 2023 Jul 1;325(1):R81-R95. doi: 10.1152/ajpregu.00057.2023. Epub 2023 May 22. PMID: 37212551; PMCID: PMC10292975.
• Bates EA, Kipp ZA, Martinez GJ, Badmus OO, Soundarapandian MM, Foster D, Xu M, Creeden JF, Greer JR, Morris AJ, Stec DE, Hinds TD Jr. Suppressing hepatic UGT1A1 increases plasma bilirubin, lowers plasma urobilin, reorganizes kinase signaling pathways and lipid species and improves fatty liver disease. Biomolecules. 2023 Jan 29;13(2):252. doi: 10.3390/biom13020252. PMID: 36830621; PMCID: PMC9953728.
• Bhattarai U, He X, Xu R, Liu X, Pan L, Sun Y, Chen JX, Chen Y. IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression. Front Immunol. 2023 Feb 13;14:1105664. doi: 10.3389/fimmu.2023.1105664. PMID: 36860846; PMCID: PMC9969090.
• Bochi APG, Ferreira GDS, Del Bianco V, Pinto PR, Rodrigues LG, Trevisani MDS, Furukawa LNS, Bispo KCS, da Silva AA, Velosa APP, Nakandakare ER, Machado UF, Teodoro WPR, Passarelli M, Catanozi S. Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice. Antioxidants (Basel). 2022 Oct 13;11(10):2023. doi: 10.3390/antiox11102023. PMID: 36290746; PMCID: PMC9598599.
• Clemmer JS, Ward TJ, Lirette ST. Retrospective analysis of SGLT2 inhibitors in heart failure with preserved ejection fraction. ESC Heart Fail. 2023 Apr 11. doi: 10.1002/ehf2.14347. Epub ahead of print. PMID: 37042079.
• Clemmer JS, Hillegass WB, Taylor EB. Antihypertensive effects of immunosuppressive therapy in autoimmune disease. J Hum Hypertens. 2023 Apr;37(4):300-306. doi: 10.1038/s41371-022-00682-0. Epub 2022 Apr 8. PMID: 35396536; PMCID: PMC9899545.
• Corrêa BSG, de Barros S, Vaz JB, Peres MA, Uchiyama MK, da Silva AA, Furukawa LNS. COVID-19: Understanding the impact of anti-hypertensive drugs and hydroxychloroquine on the ACE1 and ACE2 in lung and adipose tissue in SHR and WKY rats. Physiol Rep. 2023 Feb;11(3):e15598. doi: 10.14814/phy2.15598. PMID: 36750199; PMCID: PMC9904959.
• Didik S, Wang H, James AS, Slotabec L, Li J. Sestrin2 as a Potential Target in Hypertension. Diagnostics (Basel). 2023 Jul 14;13(14):2374. doi: 10.3390/diagnostics13142374. PMID: 37510117; PMCID: PMC10378131.
• do Carmo JM, Dai X, Aitken N, Larson KM, Omoto ACM, Gulke RR, Wang Z, Li X, Mouton AJ, Hall JE, da Silva AA. Sex differences in weight gain, blood pressure control, and responses to melanocortin-4 receptor antagonism in offspring from lean and obese parents. Am J Physiol Regul Integr Comp Physiol. 2023 Oct 1;325(4):R401-R410. doi: 10.1152/ajpregu.00106.2023. Epub 2023 Jul 31. PMID: 37519251.
• do Espírito Santo BC, Oliveira JADS, Ribeiro MADS, Schoffen RP, Polli AD, Polonio JC, da Silva AA, de Abreu Filho BA, Heck MC, Meurer EC, Constantin PP, Pileggi M, Vicentini VEP, Golias HC, Pamphile JA. Antitumor and antibacterial activity of metabolites of endophytic Colletotrichum siamense isolated from coffee (Coffea arabica L. cv IAPAR-59). Braz J Microbiol. 2023 Dec;54(4):2651-2661. doi: 10.1007/s42770-023-01104-0. Epub 2023 Aug 29. PMID: 37642890; PMCID: PMC10689633.
• Eddy AC, Chiang CY, Rajakumar A, Spradley FT, Dauer P, Granger JP, Rana S. Bioflavonoid luteolin prevents sFlt-1 release via HIF-1α inhibition in cultured human placenta. FASEB J. 2023 Aug;37(8):e23078. doi: 10.1096/fj.202300611R. PMID: 37405762; PMCID: PMC10348062.
• Fatmi MK, Ren D, Fedorova J, Zoungrana LI, Wang H, Davitt K, Li Z, Iglesias M, Lesnefsky EJ, Krause-Hauch M, Li J. Cardiomyocyte Pdk4 response is associated with metabolic maladaptation in aging. Aging Cell. 2023 Apr;22(4):e13800. doi: 10.1111/acel.13800. Epub 2023 Feb 16. PMID: 36797808; PMCID: PMC10086528.
• Flack KD, Vítek L, Fry CS, Stec DE, Hinds TD Jr. Cutting edge concepts: Does bilirubin enhance exercise performance? Front Sports Act Living. 2023 Jan 11;4:1040687. doi: 10.3389/fspor.2022.1040687. PMID: 36713945; PMCID: PMC9874874.
• Hamid A, Yimer WK, Oshunbade AA, Kamimura D, Clark D 3rd, Fox ER, Min YI, Muntner P, Shimbo D, Pandey A, Shah AM, Mentz RJ, Jones DW, Bertoni AG, Hall JE, Correa A, Butler J, Hall ME. Impact of diabetes and hypertension on left ventricular structure and function: the jackson heart study. J Am Heart Assoc. 2023 Mar 7:e026463. doi: 10.1161/JAHA.122.026463. Epub ahead of print. PMID: 36880997.
• Han H, Ma R, Xie A, Gao J, Wang Z, Zhao Y, Pang H, Zhang W. Development of an LC/MS/MS method for simultaneous detection of 11 polyphenols in rat plasma and its pharmacokinetic application after oral administration of coreopsis tinctoria extract. Chem Biodivers. 2023 Jan;20(1):e202200574. doi: 10.1002/cbdv.202200574. Epub 2022 Dec 7. PMID: 36382445.
• He X, Xu R, Pan L, Bhattarai U, Liu X, Zeng H, Chen JX, Hall ME, Chen Y. Inhibition of NK1.1 signaling attenuates pressure overload-induced heart failure, and consequent pulmonary inflammation and remodeling. Front Immunol. 2023 Jul 24;14:1215855. doi: 10.3389/fimmu.2023.1215855. PMID: 37554327; PMCID: PMC10405176.
• He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H. P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure. bioRxiv [Preprint]. 2023 Feb 9:2023.02.08.527691. doi: 10.1101/2023.02.08.527691. PMID: 36798200; PMCID: PMC9934706.
• Hinds TD Jr, Stec DE, Tiribelli C. Powering the powerhouse: heme oxygenase-1 regulates mitochondrial function in non-alcoholic fatty liver disease (NAFLD). Acta Physiol (Oxf). 2023 Mar;237(3):e13931. doi: 10.1111/apha.13931. Epub 2023 Jan 18. PMID: 36622267.
• Horwitz LI, Thaweethai T, Brosnahan SB, Cicek MS, Fitzgerald ML, Goldman JD, Granger JP, et. al. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PLoS One. 2023 Jun 23;18(6):e0286297. doi: 10.1371/journal.pone.0286297. PMID: 37352211; PMCID: PMC10289397.
• Kalusche WJ, Case CT, Taylor EB. Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease. Clin Sci (Lond). 2023 Dec 14;137(23):1771-1785. doi: 10.1042/CS20230924. PMID: 38031726; PMCID: PMC10721433.
• Kipp ZA, Martinez GJ, Bates EA, Maharramov AB, Flight RM, Moseley HNB, Morris AJ, Stec DE, Hinds TD Jr. Bilirubin nanoparticle treatment in obese mice inhibits hepatic ceramide production and remodels liver fat content. Metabolites. 2023 Feb 1;13(2):215. doi: 10.3390/metabo13020215. PMID: 36837834; PMCID: PMC9965094.
• Koubar SH, Garcia-Rivera A, Mohamed MMB, Hall JE, Hall ME, Hassanein M. Underlying Mechanisms and Treatment of Hypertension in Glomerular Diseases. Curr Hypertens Rep. 2023 Nov 20. doi: 10.1007/s11906-023-01287-9. Epub ahead of print. PMID: 37982994.
• Kozlova AA, Rubets E, Vareltzoglou MR, Jarzebska N, Ragavan VN, Chen Y, Martens-Lobenhoffer J, Bode-Böger SM, Gainetdinov RR, Rodionov RN, Bernhardt N. Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism. J Neural Transm (Vienna). 2023 Feb 16. doi: 10.1007/s00702-023-02597-7. Epub ahead of print. PMID: 36792833.
• Li Z, Wang H, Zoungrana LI, James A, Slotabec L, Didik S, Fatmi MK, Krause-Hauch M, Lesnefsky EJ, Li J. Administration of metformin rescues age-related vulnerability to ischemic insults through mitochondrial energy metabolism. Biochem Biophys Res Commun. 2023 Jun 4;659:46-53. doi: 10.1016/j.bbrc.2023.04.004. Epub 2023 Apr 5. PMID: 37031594; PMCID: PMC10190118.
• Mallette JH, Crudup B, Alexander BT. Growth restriction in preeclampsia: lessons from animal models. Science Direct. Volume 32,2023,100647; ISSN 2468-8673.
• Martin BE, Taylor EB, Attipoe EM, Wu W, Stec DE, Showmaker KC, Garrett MR. Sex and molecular differences in cardiovascular parameters at peak influenza disease in mice. Physiol Genomics. 2023 Jan 16. doi: 10.1152/physiolgenomics.00146.2022. Epub ahead of print. PMID: 36645670.
• Mouton AJ. Platelet-Derived Growth Factors: A New Therapeutic Opportunity for Treating Cardiac Fibrosis? JACC Basic Transl Sci. 2023 Jun 26;8(6):675-676. doi: 10.1016/j.jacbts.2023.01.014. PMID: 37426528; PMCID: PMC10322860.
• Mouton AJ, do Carmo JM, da Silva AA, Omoto ACM, Hall JE. Targeting immunometabolism during cardiorenal injury: roles of conventional and alternative macrophage metabolic fuels. Frontiers in Physiology 2023 April 28; 14:1139296. doi.org/10.3389/fphys.2023.1139296.
• Mouton AJ, Aitken NM, Moak, SP, do Carmo JM, da Silva AA, Omoto AM, Wang Z, Hall JE. Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction. Frontiers in Cardiovascular Medicine 2023 May 5; 10: 1136252.doi.org/10.3389/fcvm.2023.1136252.
• Omoto ACM, do Carmo JM, da Silva AA, Hall JE, Mouton AJ. Immunometabolism, extracellular vesicles and cardiac injury. Front Endocrinol (Lausanne). 2024 Jan 8;14:1331284. doi: 10.3389/fendo.2023.1331284. PMID: 38260141; PMCID: PMC10800986.
• Piñeiro-Llanes J., Stec DE, Crisofoletti R. Editorial: Insights into Emerging Technologies to Study Drug Metabolism and Transport. Frontiers in Pharmacology, section Drug Metabolism and Transport. 00:00, 2023. Accepted April 28, 2023.
• Quan N, Li X, Zhang J, Han Y, Sun W, Ren D, Tong Q, Li J. Corrigendum to "Substrate metabolism regulated by Sestrin2-mTORC1 alleviates pressure overload-induced cardiac hypertrophy in aged heart" [Redox Biol. 36 (2020) 101637/doi:10.1016/j.redox.2020.101637]. Redox Biol. 2023 Feb;59:102602. doi: 10.1016/j.redox.2023.102602. Epub 2023 Jan 8. Erratum for: Redox Biol. 2020 Sep;36:101637. PMID: 36628777; PMCID: PMC10461070.
• Ragavan VN, Nair PC, Jarzebska N, Angom RS, Ruta L, Bianconi E, Grottelli S, Tararova ND, Ryazanskiy D, Lentz SR, Tommasi S, Martens-Lobenhoffer J, Suzuki-Yamamoto T, Kimoto M, Rubets E, Chau S, Chen Y, Hu X, Bernhardt N, Spieth PM, Weiss N, Bornstein SR, Mukhopadhyay D, Bode-Böger SM, Maas R, Wang Y, Macchiarulo A, Mangoni AA, Cellini B, Rodionov RN. A multicentric consortium study demonstrates that dimethylarginine dimethylaminohydrolase 2 is not a dimethylarginine dimethylaminohydrolase. Nat Commun. 2023 Jun 9;14(1):3392. doi: 10.1038/s41467-023-38467-9. PMID: 37296100; PMCID: PMC10256801.
• Rivera-Gonzalez O, Case CT, Wilson NA, Speed JS, Taylor EB. Endothelin receptor antagonism improves glucose tolerance and adipose tissue inflammation in an experimental model of systemic lupus erythematosus. Am J Physiol Endocrinol Metab. 2023 Jan 1;324(1):E73-E84. doi: 10.1152/ajpendo.00274.2022. Epub 2022 Dec 7. PMID: 36476039; PMCID: PMC9870584.
• Shawky, Noha M, Reckelhoff, Jane M, Alexander, Barbara T, Cardoza, Licy Yanes. Insights Into the Cardiomodulatory Effects of Sex Hormones: Implications in Transgender Care. Hypertension. 2023 Sep;80(9):1810-1820. doi 10.1161/HYPERTENSIONAHA.123.19501.
• Singh S, De Carlo F, Ibrahim MA, Penfornis P, Mouton AJ, Tripathi SK, Agarwal AK, Eastham L, Pasco DS, Balachandran P, Claudio PP. The oligostilbene Gnetin H is a novel glycolysis inhibitor that regulates thioredoxin interacting protein expression and synergizes with OXPHOS inhibitor in cancer cells. Int J Mol Sci. 2023 Apr 23;24(9):7741. doi: 10.3390/ijms24097741. PMID: 37175448; PMCID: PMC10178141.
• Solise D, Campbell N, Ashraf U, Herrock O, Crudup B, Mallette J, Willis A, Rawls AZ, Turner T, Cockrell K, Zheng B, Deer E, Amaral L, Alexander BT, Lamarca B. Inhibition of angiotensin II type 1 receptor agonistic autoantibodies by direct binding does not impact reduced uterine perfusion pressure offspring birthweight and blood pressure at adulthood. Am J Obstet Gynecol MFM. 2023 Mar 27;5(6):100945. doi: 10.1016/j.ajogmf.2023.100945. Epub ahead of print. PMID: 36990181.
• Speed JS, Pollock DM, Clemmer JS. Don't sweat the small stuff: skin mechanisms of sodium homeostasis and associations with long-term blood pressure. Clin Sci (Lond). 2023 May 18;137(9):769-772. doi: 10.1042/CS20230163. PMID: 37199254; PMCID: PMC10195985.
• Sun X, Ruan C, da Silva AA. Editorial: The impact of adipose tissue dysfunction on cardiovascular and renal disease, Volume II. Front Endocrinol (Lausanne). 2023 Jun 14;14:1223983. doi: 10.3389/fendo.2023.1223983. PMID: 37388208; PMCID: PMC10303782.
• Thaweethai T, Jolley SE, Karlson EW, Levitan EB, Levy B, McComsey GA, McCorkell L, Nadkarni GN, Parthasarathy S, Singh U, Walker TA, Selvaggi CA, Shinnick DJ, Schulte CCM, Atchley-Challenner R, Alba GA, Alicic R, Altman N, Anglin K, Argueta U, Ashktorab H, Baslet G, Bassett IV, Bateman L, Bedi B, Bhattacharyya S, Bind MA, Blomkalns AL, Bonilla H, Bush PA, Castro M, Chan J, Charney AW, Chen P, Chibnik LB, Chu HY, Clifton RG, Costantine MM, Cribbs SK, Davila Nieves SI, Deeks SG, Duven A, Emery IF, Erdmann N, Erlandson KM, Ernst KC, Farah-Abraham R, Farner CE, Feuerriegel EM, Fleurimont J, Fonseca V, Franko N, Gainer V, Gander JC, Gardner EM, Geng LN, Gibson KS, Go M, Goldman JD, Grebe H, Greenway FL, Habli M, Hafner J, Han JE, Hanson KA, Heath J, Hernandez C, Hess R, Hodder SL, Hoffman MK, Hoover SE, Huang B, Hughes BL, Jagannathan P, John J, Jordan MR, Katz SD, Kaufman ES, Kelly JD, Kelly SW, Kemp MM, Kirwan JP, Klein JD, Knox KS, Krishnan JA, Kumar A, Laiyemo AO, Lambert AA, Lanca M, Lee-Iannotti JK, Logarbo BP, Longo MT, Luciano CA, Lutrick K, Maley JH, Marathe JG, Marconi V, Marshall GD, Martin CF, Matusov Y, Mehari A, Mendez-Figueroa H, Mermelstein R, Metz TD, Morse R, Mosier J, Mouchati C, Mullington J, Murphy SN, Neuman RB, Nikolich JZ, Ofotokun I, Ojemakinde E, Palatnik A, Palomares K, Parimon T, Parry S, Patterson JE, Patterson TF, Patzer RE, Peluso MJ, Pemu P, Pettker CM, Plunkett BA, Pogreba-Brown K, Poppas A, Quigley JG, Reddy U, Reece R, Reeder H, Reeves WB, Reiman EM, Rischard F, Rosand J, Rouse DJ, Ruff A, Saade G, Sandoval GJ, Schlater SM, Shepherd F, Sherif ZA, Simhan H, Singer NG, Skupski DW, Sowles A, Sparks JA, Sukhera FI, Taylor BS, Teunis L, Thomas RJ, Thorp JM, Thuluvath P, Ticotsky A, Tita AT, Tuttle KR, Urdaneta AE, Valdivieso D, VanWagoner TM, Vasey A, Verduzco-Gutierrez M, Wallace ZS, Ward HD, Warren DE, Weiner SJ, Welch S, Whiteheart SW, Wiley Z, Wisnivesky JP, Yee LM, Zisis S, Horwitz LI, Foulkes AS; RECOVER Consortium. Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA. 2023 Jun 13;329(22):1934-1946. doi: 10.1001/jama.2023.8823. PMID: 37278994; PMCID: PMC10214179.
• Vitek L, Hinds TD Jr, Stec DE, Tiribelli C. The physiology of bilirubin: health and disease equilibrium. Trends Mol Med. 2023 Feb 22:S1471-4914(23)00031-X. doi: 10.1016/j.molmed.2023.01.007. Epub ahead of print. PMID: 36828710.
• Yang C, Baker PN, Granger JP, Davidge ST, Tong C. Long-Term Impacts of Preeclampsia on the Cardiovascular System of Mother and Offspring. Hypertension. 2023 Sep;80(9):1821-1833. doi: 10.1161/HYPERTENSIONAHA.123.21061. Epub 2023 Jun 28. PMID: 37377011.
• Wang P, Gao R, Wu T, Zhang J, Sun X, Fan F, Wang C, Qian S, Li B, Zou Y, Huo Y, Fassett J, Chen Y, Ge J, Sun A. Accumulation of endogenous adenosine improves cardiomyocyte metabolism via epigenetic reprogramming in an ischemia-reperfusion model. Redox Biol. 2023 Nov;67:102884. doi: 10.1016/j.redox.2023.102884. Epub 2023 Sep 13. PMID: 37725888; PMCID: PMC10507380.
• Wang Z, Hu S, Wu X, He Z, Ke C, Hu M. A highly sensitive LC-MS/MS method for the determination and quantification of a recently identified N-nitrosamine impurity in the sitagliptin phosphate monohydrate active pharmaceutical ingredient. Anal Methods. 2023 Jan 19;15(3):256-260. doi: 10.1039/d2ay01821g. PMID: 36598084.
• Williamson A, da Silva A, do Carmo JM, Le Maitre CL, Hall JE, Aberdein N. Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight. Physiol Rep. 2023 Oct;11(19):10.14814/phy2.15832. doi: 10.14814/phy2.15832. PMID: 37786973; PMCID: PMC10546263.
• Xiang L, Clemmer JS, McCully BH. Editorial: Shock and resuscitation. Front Physiol. 2023 Jul 7;14:1231691. doi: 10.3389/fphys.2023.1231691. PMID: 37485058; PMCID: PMC10361610.
• Yang C, Baker PN, Granger JP, Davidge ST, Tong C. Long-Term Impacts of Preeclampsia on the Cardiovascular System of Mother and Offspring. Hypertension. 2023 Sep;80(9):1821-1833. doi: 10.1161/HYPERTENSIONAHA.123.21061. Epub 2023 Jun 28. PMID: 37377011.
• Zhang J, Wang H, Slotabec L, Cheng F, Tan Y, Li J. Alterations of SIRT1/SIRT3 subcellular distribution in aging undermine cardiometabolic homeostasis during ischemia and reperfusion. Aging Cell. 2023 Sep;22(9):e13930. doi: 10.1111/acel.13930. Epub 2023 Aug 3. PMID: 37537789; PMCID: PMC10497814.
• Zhuo Y, Wang M, Liu Z, Xu W, Abdulnazar A, Rajabi AM, Davletbakov A, Haider J, Khan MZ, Loik N, Faryabi SP, Michel S, Ostrowski S, Moheb Z, Ruckstuhl K, da Silva AA, Alves J, Yang W. Border fences reduce potential for transboundary migration of Marco Polo Sheep (Ovis ammon polii) in the Pamir Plateau. Sci Total Environ. 2024 Feb 20;912:169298. doi: 10.1016/j.scitotenv.2023.169298. Epub 2023 Dec 20. PMID: 38128653.
• Zoungrana LI, Krause-Hauch M, Wang H, Fatmi MK, Li Z, Slotabec L, James AS, Didik S, Li J. Activated protein C signaling mediates neuroinflammation in seizure induced by pilocarpine. Biochem Biophys Rep. 2023 Sep 29;35:101550. doi: 10.1016/j.bbrep.2023.101550. PMID: 37823005; PMCID: PMC10562752.
• Zoungrana LI, Didik S, Wang H, Slotabec L, Li J. Activated protein C in epilepsy pathophysiology. Front Neurosci. 2023 Oct 13;17:1251017. doi: 10.3389/fnins.2023.1251017. PMID: 37901428; PMCID: PMC10603301.